Table 2.

List of in vivo effects of α-amylase inhibitors reported from several plant extracts.

Plant Extracts	Dosage of Plant Extract Used	Experimental Animals	Types of Diabetes Induction	Administration Route	Diagnostic Criteria	Inference	Ref.
Oxalis pes-caprae Methanolic extract	150 mg/kg BW	Swiss albino mice	Alloxan-induced diabetes	Intraperitoneal injection	Fasting blood glucose (FBG) level, body weight	Hypoglycemic	[122]
Cardamine hirsuta Linn Hydro-methanolic extract	125, 250, and 500 mg/kg BW	Male Sprague Dawley (SD) rats	High-fat diet (HFD), Streptozotocin (STZ)-induced diabetes	Oral and intraperitoneal injection	FBG level	Hypoglycemic, dose-dependent	[123]
Trachinotus ovatus Protein hydrolysates	100, 500, and 1000 mg/kg BW	Male Kunming mice	STZ-induced diabetes	Intraperitoneal injection	FBG level	Hypoglycemic, dose-dependent	[124]
Sorbaria tomentosa Lindl. Rehder Methanolic extract	150 and 300 mg/kg BW	Rats	Alloxan-induced diabetes	Intraperitoneal injection	FBG level	Hypoglycemic	[125]
Chenopodium album L. Flavonoid fraction	500 mg/kg BW	SD rats	HFD-STZ-induced diabetes	Oral and intraperitoneal injection	Glucose, cholesterol, and triglyceride levels	Hypoglycemic	[91]
Terfezia claveryi Methanolic extract	200 mg/kg BW	Male Wistar albino rats	STZ-induced diabetes	Intraperitoneal injection	FBG level	Hypoglycemic time-dependent	[80]
Salvia lavandulifolia Vahl Aqueous extract	400 mg/kg BW	Normal rats	D-glucose, 2 g/kg	Oral	Oral glucose tolerance test (OGTT) Blood glucose level	Hypoglycemic	[96]
Artemisia absinthium L. Aqueous extract	200 mg/kg BW	Wistar rats	Alloxan-induced diabetes	Oral	Postprandial blood glucose (PBG) level	Hypoglycemic	[126]
Ammodaucus leucotrichus Coss. and Durieu Aqueous extract	150 mg/kg BW	Wistar albino rats	Alloxan-induced diabetes	Oral	OGTT	Hypoglycemic	[127]
Porphyra spp. Polysaccharides	100 mg/kg BW	Rats	-	Oral	PBG level	Hypoglycemic	[128]
Prosopis cineraria Ethyl acetate fraction/n-Butanol fraction	250, 500, 1000 and 2000 mg/kg BW	Swiss albino mice	Sucrose tolerance test (OSTT)	Oral	Serum glucose concentration	Hypoglycemic	[78]
Allium sativum L. Polysaccharides	1.25, 2.5, and 5 g/kg BW	Male Kunming mice	STZ-induced diabetes	Intraperitoneal injection	OGTT, FBG	Hypoglycemic	[129]