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. 2023 Aug 14;16(8):1151. doi: 10.3390/ph16081151

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Histopathological alterations are affected (10×) by RZ-NLCs and RZ-NLCsG. Normal architecture is seen in the vehicle-treated group, but myonecrosis, inflammation, and edema are seen in the vasopressin-control group. When compared to those treated with the RZ-NLCsG group, it exhibits considerable skin protection by reducing myonecrosis, edema, and inflammation. (B) Severity score for blinded histological evaluation in comparison to RZ-NLCsG-treated group. Values are expressed in mean ± SD, n = 3 * p > 0.05, ** p > 0.02, *** p > 0.001.