Table 1.

Optimization of RZ-NLC formulation by Box-Behnken statistical design.

Std	X1	X2	X3	Y1	Y2	Y3	Y4
1	187.5	22.5	25	65.81 ± 2.3	264.3 ± 5.39	0.394 ± 0.043	−29.6 ± 1.26
2	187.5	22.5	25	65.81 ± 2.3	264.3 ± 5.39	0.394 ± 0.043	−29.6 ± 1.26
3	187.5	15	20	74.39 ± 4.9	215.4 ± 6.5	0.291 ± 0.012	−31.4 ± 1.05
4	187.5	22.5	25	65.81 ± 2.3	264.3 ± 5.39	0.394 ± 0.043	−29.6 ± 1.26
5	187.5	22.5	25	65.81 ± 2.3	264.3 ± 5.39	0.394 ± 0.043	−29.6 ± 1.26
6	225	22.5	20	82.34 ± 2.6	159.7 ± 6.4	0.218 ± 0.028	−35.4 ± 2.15
7	187.5	22.5	25	59.37 ± 2.3	264.3 ± 5.39	0.394 ± 0.043	−29.6 ± 1.26
8	225	30	25	88.39 ± 3.1	159.3 ± 3.1	0.168 ± 0.033	−38.7 ± 0.61
9	187.5	30	20	78.43 ± 2.4	173.4 ± 8.6	0.235 ± 0.152	−30.2 ± 0.98
10	187.5	30	30	80.19 ± 6.3	194.2 ± 3.33	0.198 ± 0.032	−39.4 ± 2.15
11	150	22.5	30	76.38 ± 1.8	182.3 ± 2.84	0.167 ± 0.051	−41.9 ± 1.38
12	187.5	15	30	82.16 ± 4.5	118.4 ± 5.94	0.135 ± 0.038	−39.4 ± 1.52
13	225	22.5	30	74.52 ± 1.9	182.9 ± 3.51	0.184 ± 0.015	−38.4 ± 0.68
14	225	15	25	69.31 ± 8.3	238.6 ± 6.25	0.326 ± 0.102	−35.2 ± 1.53
15	150	22.5	20	60.28 ± 6.4	215.3 ± 3.38	0.314 ± 0.038	−28.4 ± 0.75
16	150	15	25	76.18 ± 5.2	153.1 ± 5.13	0.158 ± 0.028	−36.4 ± 2.38
17	150	30	25	59.43 ± 7.3	294.8 ± 2.49	0.372 ± 0.125	−34.6 ± 3.24