Table 1.

Nrf2 promotes monocyte and macrophage tissue invasion in a broad range of disease states

Although the function of Nrf2 is most commonly described as anti-inflammatory, Nrf2 actively promotes inflammation and monocyte and macrophage invasion into damaged epithelial tissues across a range of mouse disease models, and in multiple tissue types.

Disease Model	Experimental System	NRF2 phenotype	Reference
Steatohepatitis	Hepatocyte-specific NEMO CKO mouse	Keap1 DKO mice exhibit increased monocyte-derived	[53]
		macrophages in the diseased livers
DSS-induced colitis	Adipocyte-specific Atg7 CKO mouse	Nrf2 activation by the non-canonical p62 pathway resulted	[54]
		in increased monocyte invasion into the damage colons
Pancreatitis	Pancreatic acinar-specific VMP1 CKO mouse	Nrf2 DKO mice exhibit decreased inflammation and	[55]
		macrophage infiltration into the damaged pancreases
Autoimmune nephritis	Fas mutant lpr/lpr mice	Nrf2 DKO mice exhibit decreased macrophage, CD4	[56]
		and CD8 T cell infiltration into the damaged kidneys
Lung cancer	scRNA-Seq analysis of human lung tumours	KEAP1 mutant tumours are enriched with proinflammatory	[57]
		monocyte-derived macrophages (CP2E pattern)