Abstract
A man with a history of treatment for early syphilis presented with tabes dorsalis. Despite receiving a course of penicillin accepted as adequate by the World Health Organisation the illness progressed to tabo-paresis after 20 years. Reinfection cannot be excluded.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COLLART P., BOREL L. J., DUREL P. [Study of the effect of penicillin in late syphilis: persistence of Treponema pallidum following treatment. 1. Late syphilis--expeimental]. Ann Inst Pasteur (Paris) 1962 May;102:596–615. [PubMed] [Google Scholar]
- DATTNER B. Penicillin failures in neurosyphilis. Am J Syph Gonorrhea Vener Dis. 1949 Nov;33(6):571–575. [PubMed] [Google Scholar]
- Dowzenko A., Krysztofiak B. Relapses in the cerebrospinal fluid and acquired resistance to penicillin in cases of neurosyphilis. J Neurol Sci. 1965 Mar-Apr;2(2):197–202. doi: 10.1016/0022-510x(65)90080-8. [DOI] [PubMed] [Google Scholar]
- HAHN R. D. Some remarks on the management of neurosyphilis. J Chronic Dis. 1961 Jan;13:1–5. doi: 10.1016/0021-9681(61)90040-6. [DOI] [PubMed] [Google Scholar]
- Martin J. P. Conquest of general paralysis. Br Med J. 1972 Jul 15;3(5819):159–160. doi: 10.1136/bmj.3.5819.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mohr J. A., Griffiths W., Jackson R., Saadah H., Bird P., Riddle J. Neurosyphilis and penicillin levels in cerebrospinal fluid. JAMA. 1976 Nov 8;236(19):2208–2209. [PubMed] [Google Scholar]
- Tramont E. C. Persistence of Treponema pallidum following penicillin G therapy. Report of two cases. JAMA. 1976 Nov 8;236(19):2206–2207. [PubMed] [Google Scholar]
- Wilner E., Brody J. A. Prognosis of general paresis after treatment. Lancet. 1968 Dec 28;2(7583):1370–1371. doi: 10.1016/s0140-6736(68)92674-3. [DOI] [PubMed] [Google Scholar]
- Yoder F. W. Penicillin treatment of neurosyphilis. Are recommended dosages sufficient? JAMA. 1975 Apr 21;232(3):270–271. [PubMed] [Google Scholar]