Table 3.

Summary of Dosing and Up-Titration Schedules for Cohorts 1 to 4 (Pediatric Participants with Autism Spectrum Disorder)

Intervention/postintervention day	10–17 years				5–9 years
	Cohort 1		Cohort 2		Cohort 3	Cohort 4
	10–12 years, 0.75 mg/day	13–17 years, 1.5 mg/day	10–12 years, 1.5 mg/day	13–17 years, 3.0 mg/day	0.5 mg/day	1.5 mg/day
	N = 6		N = 6		N = 6	N = 6
Day 1, mg (mL)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)
Day 2, mg (mL)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)
Day 3, mg (mL)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)	0.5 (1)
Day 4, mg (mL)	0.75 (1.5)	1.5 (3)	1.5 (3)	1.5 (3)	0.5 (1)	1.5 (3)
Day 5, mg (mL)	0.75 (1.5)	1.5 (3)	1.5 (3)	1.5 (3)	0.5 (1)	1.5 (3)
Day 6, mg (mL)	0.75 (1.5)	1.5 (3)	1.5 (3)	1.5 (3)	0.5 (1)	1.5 (3)
Days 7–42	0.75 (1.5)	1.5 (3)	1.5 (3)	3.0 (6)	0.5 (1)	1.5 (3)
Days 43–84	PK follow-up	PK follow-up	PK follow-up	PK follow-up	PK follow-up	PK follow-up

PK, pharmacokinetics.