Table 6.
Spearman's Correlations of Microvascular Injury-Related Biomarkers With Secondary 6-Month Outcomes
| RPQ | SWLS | BSI-18 | CVLT | TMT-A | TMT-B | WAIS-PSI | |
|---|---|---|---|---|---|---|---|
| A priori hypothesized | |||||||
| vWF | -0.08 | 0.00 | 0.00 | 0.10 | -0.05 | -0.09 | 0.12 |
| Thrombomodulin | 0.08 | 0.06 | -0.03 | -0.03 | -0.01 | 0.14 | 0.00 |
| Ang-1 | -0.06 | 0.04 | -0.06 | 0.00 | 0.13 | 0.08 | 0.03 |
| Ang-2 | -0.14 | 0.07 | -0.21 | -0.08 | 0.15 | 0.18 | -0.06 |
| c-Fibronectin | 0.05 | 0.09 | -0.07 | -0.25* | -0.05 | -0.01 | -0.05 |
| Tie-2 | -0.04 | 0.06 | 0.04 | 0.05 | 0.12 | 0.11 | 0.00 |
| Exploratory | |||||||
| Flt-1 | -0.02 | 0.04 | -0.03 | -0.04 | 0.08 | 0.11 | 0.01 |
| PIGF | -0.03 | 0.04 | -0.13 | 0.09 | 0.01 | 0.07 | 0.18 |
| VEGF-A | -0.05 | 0.02 | -0.04 | 0.03 | 0.08 | 0.05 | 0.17 |
| VEGF-C | -0.02 | 0.00 | 0.03 | -0.02 | 0.16 | 0.09 | 0.05 |
| VEGF-D | 0.08 | -0.13 | 0.06 | 0.04 | 0.06 | 0.02 | 0.07 |
| E-Selectin | 0.16 | -0.07 | 0.12 | -0.19 | -0.06 | 0.14 | -0.11 |
| PDGFR-ß | 0.03 | -0.04 | -0.08 | 0.03 | -0.11 | -0.06 | 0.08 |
| P-Selectin | 0.00 | 0.11 | -0.16 | -0.21 | 0.04 | 0.09 | 0.04 |
| VCAM-1 | 0.11 | -0.14 | -0.01 | 0.03 | 0.13 | 0.13 | 0.03 |
| bFGF | -0.04 | 0.16 | -0.09 | 0.04 | 0.14 | 0.08 | 0.16 |
| Principal Components Analysis | |||||||
| PC1 | -0.04 | 0.04 | 0.00 | -0.01 | 0.12 | 0.05 | 0.10 |
| PC2 | 0.01 | 0.00 | -0.01 | -0.14 | 0.08 | 0.20 | -0.06 |
p < 0.05
Sample size for c-Fibronectin is 135; sample size for all other biomarkers and principal components analysis is 159.
RPQ, Rivermead Post-Concussion Symptoms Questionnaire; SWLS, Satisfaction with Life Scale; BSI-18, 18-Item Brief Symptom Inventory; CVLT, California Verbal Learning Test; TMT, Trail Making Test; WAIS-PSI, Processing Speed Index from the Wechsler Adult Intelligence Scale, 4th Edition; vWF, von Willebrand factor; Ang, angiopoietin; PIGF, placental growth factor; VEGF, vascular endothelial growth factor; PDGFR, platelet-derived growth factor receptor; VCAM-1, vascular cell adhesion protein 1; bFGF, basic fibroblast growth factor; PC, principal component.