Table 1.
Characteristics of Mild TBI Patients With Available 6-Month Glasgow Outcome Scale Extended (GOSE; N = 2376) and Rivermead Post-Concussion Symptoms Questionnaire (RPQ; n = 1605), and 2-Week RPQ (n = 640; n = 476) in the CENTER-TBI Study
| |
6-month GOSE |
|
6-month RPQ |
|
6-Month GOSE +2-3-week RPQ |
|
6-Month 2-3-week RPQ |
|
|---|---|---|---|---|---|---|---|---|
| n | 2376 | Missing % | 1605 | Missing % | 640 | Missing % | 476 | Missing % |
| Age median [Q1, Q3] | 53 [34, 68] | 0 | 53[35, 66] | 0 | 49[31, 62] | 0 | 51[34.75, 63] | 0 |
| Sex male (%) | 1519 (63.9) | 0 | 1018 (63.4) | 0 | 378 (59.1) | 0 | 279 (58.6) | 0 |
| Pre-injury health ASA-PS (%) | 0.8 | 0.4 | 0 | 0 | ||||
| No systemic disease | 1292 (54.8) | 909 (56.9) | 383 (59.8) | 383 (59.8) | ||||
| Mild | 803 (34.1) | 538 (33.7) | 2024 (31.9) | 158 (33.2) | ||||
| Severe | 261 (11.1) | 151 (9.4) | 53 (8.3) | 39 (8.2) | ||||
| Psychiatric history (%) | 312 (13.3) | 1 | 202 (12.6) | 0.5 | 86 (13.5) | 0.2 | 62 (13.0) | 0 |
| Cause of injury (%) | 1.8 | 1.6 | 1.1 | 1.3 | ||||
| fall and other | 1353 (58.0) | 888 (56.2) | 373 (58.9) | 268 (57.0) | ||||
| Traffic | 846 (36.2) | 613 (38.8) | 226 (35.7) | 185 (39.4) | ||||
| violence | 135 (5.8) | 78 (4.9) | 34 (5.4) | 17 (3.6) | ||||
| Glasgow Coma Score (%) | 0 | 0 | 0 | 0 | ||||
| 13 | 161 (6.8) | 103 (6.4) | 15 (2.3) | 12 (2.5) | ||||
| 14 | 421 (17.7) | 269 (16.8) | 56 (8.8) | 39 (8.2) | ||||
| 15 | 1794 (75.5) | 1233 (76.8) | 569 (88.9) | 425 (89.3) | ||||
| Total Injury Severity Score (ISS) median[Q1-Q3] |
10 [5, 18] | 0.9 | 10[5, 18] | 0.7 | 5 [2, 9] | 0.2 | 5[2.75, 9] | 0 |
| ISS extra-cranial | 3[0,9] | 0 | 4[0,9] | 0 | 1[0,4] | 0 | 1[0,4] | 0 |
| Head AIS | 3[2,3] | 1 | 3[2,3] | 0.8 | 2[1,2] | 0.3 | 2[1,2] | 0.2 |
| Any intracranial abnormality (%) | 1028 (46.3) | 6.6 | 718 (47.4) | 5.5 | 113 (18.6) | 5.2 | 98 (21.4) | 3.6 |
| NFL ≤48 h median [Q1, Q3] |
13.5 [7.2, 28.5] | 20.4 | 12.8 [7.3, 25.7] | 18.2 | 8.4[5.2, 14.4] | 16.4 | 8.8[5.6, 14.4] | 13.7 |
| RPQ Total Score at presentation1 median [Q1, Q3] |
8 [2, 15] | 29.4 | 8 [2.75, 15] | 26.2 | 8 [2, 15.75] | 10.9 | 8.50 [2, 16] | 11.3 |
| RPQ Total Score at 2-3 wks2 median [Q1, Q3] | 8 [0, 20] | 73.1 | 8[2, 21] | 70.3 | 8[0, 20] | 0 | 8 [2, 21] | 0 |
| RPQ Total Score at 6 months median [Q1, Q3] | 6 [0, 16] | 32.5 | 6 [0, 16] | 0 | 4 [0, 14] | 25.6 | 4 [0, 14] | 0 |
| GOSE at 180 days | 0 | 0.1 | 0 | 0 | ||||
| 1 | 89 (3.7) | 0 | 1 (0.2) | 0 | ||||
| 3 | 99 (4.2) | 42 (2.6) | 8 (1.2) | 4 (0.8) | ||||
| 4 | 74 (3.1) | 53 (3.3) | 1 (0.2) | 1 (0.2) | ||||
| 5 | 174 (7.3) | 119 (7.4) | 27 (4.2) | 21 (4.4) | ||||
| 6 | 247 (10.4) | 205 (12.8) | 53 (8.3) | 49 (10.3) | ||||
| 7 | 517 (21.8) | 410 (25.6) | 133 (20.8) | 118 (24.8) | ||||
| 8 | 1176 (49.5) | 775 (48.3) | 417 (65.2) | 283 (59.5) |
1
At median 1 day post-injury [Q1:Q3: 0-1].
2
At median 20 days [Q1-Q3:15-28]).
TBI, traumatic brain injury; CENTER-TBI, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury; ASA- PS, American Society of Anesthesiologists Physical Status classification; AIS, Abbreviated Injury Score; NFL, neurofilament light.