Table 2.

Prognostic Models for 6-Month Glasgow Outcome Scale Extended (GOSE) After Mild TBI: Model Performance (N = 2376)

	Core model	Clinical model	Clinical +early symptoms (RPQ)	Clinical +CT	Clinical +Biomarkers	Clinical+ early symptoms, CT, biomarkers	Clinical +2-3–week symptoms [subset n = 640]
	Ordinal GOSE (1-8)
Nagelkerke R2 (optimism-corrected)	0.18	0.21	0.22	0.24	0.23	0.26	0.21
C (optimism- corrected) 95% CI	0.68 [0.68-0.70]	0.70 [0.69-0.71]	0.71 [0.69-0.72]	0.71 [0.70-0.72]	0.71 [0.70 -0.72]	0.72 [0.71-0.73]	0.74 [0.71-0.78]
	C (optimism-corrected) for different cutoffs
GOSE = 81	0.69	0.70	0.72	0.71	0.71	0.73	0.75
GOSE ≥72	0.73	0.74	0.75	0.75	0.76	0.76	0.76
GOSE ≥53	0.79	0.80	0.80	0.80	0.82	0.81	0.69**

^** Only 10 outcome events.

¹ Complete vs. incomplete recovery/death.

² Good recovery vs. disability/death.

³ Moderate disability/good recovery (“favorable”) vs. severe disability/death (“unfavorable”).

TBI, traumatic brain injury; RPQ, Rivermead Post-Concussion Symptoms Questionnaire; CT, computed tomography; C, concordance index; CI, confidence Interval.