Table 2.

An overview of the most important lncRNAs associated with T-ALL.

	Alteration	Target	Function	Ref.
SNHG1	Upregulated	miR 124-3P	Promotes cell proliferation and migration	[107]
PVT1	Upregulated	miR-486-5p, NOP2 and Myc	Increases cell viability, deregulates cell cycle, and inhibits apoptosis	[97]
ARIEL	Upregulated	ARID5B	Increases cell growth and survival	[93]
LUNAR1	Upregulated	IGF1R	Increases cell growth	[99,108]
NALT	Upregulated	Notch signaling	Induces cell proliferation	[100]
NEAT1	Upregulated	miR-146b-5p	Promotes cell proliferation and growth	[101]
AWPPH	Upregulated	ROCK2	Promotes cell proliferation and inhibits apoptosis	[104]
T-ALL-R-LncR1	Upregulated	Par-4/THAP1 protein complex	Inhibits apoptosis	[105]
H19	Upregulated	SOX2, OCT4 and NANOG	Maintains stemness, promotes cell proliferation, and inhibits apoptosis	[102,109]
LINC00853	Downregulated	CCR9 expression	Inhibits cell proliferation and migration	[110]
EBLN3P	Upregulated	miR-655-3p	Increases proliferation, invasion, and migration	[106]
PPM1A-AS	Upregulated	Notch, PI3K-AKT, and JAK-STAT signaling	Regulates cell proliferation and apoptosis	[111]
LINC00478	Upregulated	mir-125b	Increases cell growth and invasiveness	[112]

SNHG1: small nucleolar RNA host gene 1; PVT1: plasmacytoma variant translocation 1; ARIEL: ARID5B inducing enhancer associated long noncoding RNA; LUNAR1: leukemia-induced noncoding activator RNA; NALT: NOTCH1 associated lncRNA in T-ALL; NEAT1: nuclear enriched abundant transcript 1; AWPPH: long non-coding RNA associated with poor prognosis of hepatocellular carcinoma; T-ALL-R-LncR1: T-ALL-related long non-coding RNA; LINC00853: long intergenic non-protein coding RNA 853; EBLN3P: endogenous bornavirus-like nucleoprotein; PPM1A-AS: protein phosphatase 1A antisense RNA; LINC00478: long intergenic non-protein coding RNA 478.