Table 2.
SARS-CoV-2 Variants | IC50 (μM, Mean ± SD) | ||||
---|---|---|---|---|---|
Perphenazine | Fluphenazine Decanoate | Acepromazine Maleate | Prochlorperazine Maleate | Alimemazine Hemitartrate | |
B.1.1.7 (Alpha) | 1.315 ± 0.283 | 2.680 ± 0.370 | 2.580 ± 0.494 | 0.526 ± 0.103 | 0.580 ± 0.084 |
B.1.351 (Beta) | 1.215 ± 0.225 | 1.736 ± 0.518 | 3.152 ± 0.602 | 0.293 ± 0.027 | 0.293 ± 0.059 |
P.1 (Gamma) | 0.487 ± 0.169 | 6.214 ± 1.211 | 1.719 ± 0.348 | 0.762 ± 0.100 | 1.526 ± 0.339 |
B.1.429 (Epsilon) | 0.802 ± 0.125 | 1.200 ± 0.425 | 4.605 ± 1.068 | 0.113 ± 0.034 | 0.342 ± 0.103 |
B.1.526 (lota) | 0.315 ± 0.042 | 4.525 ± 2.615 | 1.298 ± 0.196 | 0.31 ± 0.045 | 1.040 ± 0.574 |
B.1.617.1 (Kappa) | 0.343 ± 0.075 | 3.957 ± 0.762 | 0.661 ± 0.161 | 0.249 ± 0.057 | 0.609 ± 0.082 |
B.1.617.2 (Delta) | 0.903 ± 0.211 | 9.318 ± 3.236 | 2.496 ± 0.583 | 0.609 ± 0.128 | 1.776 ± 0.660 |
C.37 (Lambda) | 0.482 ± 0.059 | 2.270 ± 0.419 | 1.993 ± 0.576 | 0.423 ± 0.096 | 0.342 ± 0.097 |
a The data are presented as mean ± SD of three independent experiments.