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. 2023 Jul 31;15(8):1666. doi: 10.3390/v15081666

Table 2.

Inhibitory activities of phenothiazines against SARS-CoV-2 variant PsVs infection a.

SARS-CoV-2 Variants IC50 (μM, Mean ± SD)
Perphenazine Fluphenazine Decanoate Acepromazine Maleate Prochlorperazine Maleate Alimemazine Hemitartrate
B.1.1.7 (Alpha) 1.315 ± 0.283 2.680 ± 0.370 2.580 ± 0.494 0.526 ± 0.103 0.580 ± 0.084
B.1.351 (Beta) 1.215 ± 0.225 1.736 ± 0.518 3.152 ± 0.602 0.293 ± 0.027 0.293 ± 0.059
P.1 (Gamma) 0.487 ± 0.169 6.214 ± 1.211 1.719 ± 0.348 0.762 ± 0.100 1.526 ± 0.339
B.1.429 (Epsilon) 0.802 ± 0.125 1.200 ± 0.425 4.605 ± 1.068 0.113 ± 0.034 0.342 ± 0.103
B.1.526 (lota) 0.315 ± 0.042 4.525 ± 2.615 1.298 ± 0.196 0.31 ± 0.045 1.040 ± 0.574
B.1.617.1 (Kappa) 0.343 ± 0.075 3.957 ± 0.762 0.661 ± 0.161 0.249 ± 0.057 0.609 ± 0.082
B.1.617.2 (Delta) 0.903 ± 0.211 9.318 ± 3.236 2.496 ± 0.583 0.609 ± 0.128 1.776 ± 0.660
C.37 (Lambda) 0.482 ± 0.059 2.270 ± 0.419 1.993 ± 0.576 0.423 ± 0.096 0.342 ± 0.097

a The data are presented as mean ± SD of three independent experiments.

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