Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 1;15(8):2068. doi: 10.3390/pharmaceutics15082068

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Small-angle X-ray scattering (SAXS) investigation. (A) SAXS patterns of different LNP formulations in phosphate buffer (pH 4.5, light blue) and application buffer (pH 5.7, dark blue). Formulations are displayed according to their composition with PEG-grafted LNPs (left) and pSar-grafted LNPs (right) and their ionizable and helper lipid are displayed right to the scattering patterns. Scattering patterns are vertically shifted for better visualization. (B) Comparison between LNP formulations in d-spacing (top). Investigated pairs generated with formulations only differing in one lipid component (ionizable lipid, helper lipid, stealth lipid). Mean of the differences in the compared formulations is shown on the right and represents the mean factor in which the formulations differ in d-spacing when comparing the investigated pairs; the same procedure for correlation length is at the bottom. Data displayed as mean ± S.D.