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Apparent pKa of all LNP formulations via fluorescence-based 2-(p-toluidino)-6- naphthalene sulfonic acid (TNS) assay. Data presented as mean ± S.D., n = 3.
| Formulation (DODMA) |
Apparent pKa | Formulation (MC3) |
Apparent pKa |
|---|---|---|---|
| LNP 1 | 6.5 ± 0.0 | LNP 5 | 6.7 ± 0.0 |
| LNP 2 | 6.5 ± 0.1 | LNP 6 | 6.6 ± 0.0 |
| LNP 3 | 6.5 ± 0.2 | LNP 7 | 6.5 ± 0.1 |
| LNP 4 | 6.6 ± 0.1 | LNP 8 | 6.5 ± 0.1 |
