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. 2023 Aug 15;16(8):1162. doi: 10.3390/ph16081162

Table 1.

FDA-Approved Fluorinated (F-18) Radiolabeled Drugs.

Name Structure Mode of Action/Uses References
Flortaucipir F-18 graphic file with name pharmaceuticals-16-01162-i001.jpg Small lipophilic tracer containing 18F capable of crossing the blood–brain barrier and binding to aggregated tau proteins; used in PET imaging for the diagnosis of Alzheimer’s disease. [43]
Fluciclovine F-18 Inline graphic Transported into prostate cancer cells via ASCT2 and LAT1 transporters. [44]
Fluorodopa F-18 graphic file with name pharmaceuticals-16-01162-i003.jpg Decarboxylated by aromatic amino acid decarboxylase (AADC) in the striatum to fluorodopa F-18. Fluorodopa F-18 is then further metabolized by monoamine oxidase (MAO) to yield 18F 6-fluoro-3,4-dihydroxyphenylacetic acid. [45]
Fluoroestradiol F-18 graphic file with name pharmaceuticals-16-01162-i004.jpg Radioactive diagnostic agent for the detection of estrogen receptor-positive lesions. [46]
Piflufolastat F-18 graphic file with name pharmaceuticals-16-01162-i005.jpg Binds to PSMA and allows for the visualization of PSMA-positive lesions associated with prostate cancer. [47]