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Dose-dependent inhibition of LPS-induced TLR4 signaling by βα-DLAMs. (A) Inhibition of E. coli O111:B4 LPS-induced IL-8 release in hTLR4/hMD-2/hCD14—transfected HEK293 cells comparted to TLR4 antagonists DA193 and DA256; (B) inhibition of E. coli O111:B4 LPS-induced IL-8 release in mTLR4/mMD-2—transfected HEK293 cells comparted to TLR4 antagonists DA193 and DA256. Data were combined from n = 3 independent experiments, error bars indicate standard error of the mean.
