Table 2.
Comparative range of harmful and potentially harmful constituents (HPHCs; per stick or cigarette) present in the heated tobacco product mainstream aerosol (HTP aerosol) and mainstream smoke of traditional combustible cigarettes (TCC smoke) [4,10,11,12,13,14,15]. Blanks (-) indicate not reported/not quantified/below level of detection. Single values are provided where ranges could not be obtained. ISO, HCI, and CORESTA puffing regimens were used. Reported HTP aerosol data were obtained from tobacco- and menthol-flavoured HTP sticks. TCC smoke data were obtained from reference-grade (3R4F, 1R6F) and Marlboro Red 100 cigarettes.
| (Per Cigarette) | HTP Stick | TCC Cigarette |
|---|---|---|
| Nicotine (mg) | 4.7–5.1 | 8.7–15.0 |
| Tobacco-specific nitrosamines (TSNAs) (ng) | ||
| N-Nitrosonornicotine (NNN) | 94.4–101.0 | 1899.0–1691.0 |
| N’-Nitrosoanatabine (NAT) | 94.5–99.8 | 913.0–1341.0 |
| N-Nitrosoanabasine (NAB) | 2.6–5.6 | 46.0–65.0 |
| Nicotine-derived nitrosoamine ketone (NNK) | 51.1–58.2 | 412.0–532.0 |
| HTP Aerosol | TCC Smoke | |
| Total particulate matter (mg) | 12.9–55.8 | 9.8–37.7 |
| % Free base | 5.7–13.6 | 5.8–14.5 |
| Tar (mg) | 7.5–16.6 | 8.0–25.50 |
| Propylene glycol (mg) | 0.2–0.6 | - |
| Glycerin (mg) | 1.6–3.8 | 0.80–2.3 |
| Nicotine (mg) | 0.5–1.5 | 0.7–2.1 |
| Carbon monoxide (mg) | 0.3–0.5 | 11.2–33.0 |
| TSNAs (ng) | ||
| NNN | 5.00–24.9 | 92.1–311.1 |
| NAT | 6.1–37.2 | 92.9–246.4 |
| NAB | 2.6–5.5 | 9.60–30.4 |
| NNK | 3.5–13.8 | 85.50–250.4 |
| Aromatic amines (ng) | ||
| 1-Aminonaphthalene | - | 10.6–21.6 |
| 2-Aminonaphthalene | - | 5.7–10.1 |
| 3-Aminobiphenyl | - | 2.0–4.2 |
| 4-Aminobiphenyl | - | 1.0–2.2 |
| Hydrogen cyanide (µg) | - | 70.9–319.0 |
| Ammonia (µg) | 2.4–10.5 | 11.1–28.7 |
| Phenol (µg) | 1.2 | 7.0–14.8 |
| Polycyclic aromatic hydrocarbon (PAH) Benzo(a)pyrene (ng) | - | 6.7–16.2 |
| Reactive oxygen species (nmol H2O2) | 6.3 | 10.7–46.8 |
| Gas phase | 1.9 | 2.3–2210 |
| Particle phase | 4.3 | 7.8–24.7 |
| Particulate-phase radicals (pmol) | - | 79.4 |
| Volatile organic compounds (µg) | ||
| 1,3-Butadiene | 0.5 | 38.5–76.5 |
| Isoprene | 0.6–3.0 | 395.0–863.0 |
| Acrylonitrile | 0.2 | 26.4–67.0 |
| Benzene | 0.1 –0.6 | 47.7–104.0 |
| Toluene | 0.8–2.5 | 73.6–208.0 |