Table 3.
Comparative range of harmful and potentially harmful constituents (HPHCs, per cigarette) present in the heated tobacco product mainstream aerosol (HTP aerosol), mainstream smoke of traditional combustible cigarettes (TCC smoke), and electronic cigarette mainstream aerosol (ECIG aerosol) [4,10,11,12,13,14,15]. Blanks (-) indicate not reported/not quantified/below level of detection. Single values are provided where ranges could not be obtained. ISO, HCI, and CORESTA puffing regimens were used. Reported HTP aerosol data were obtained from tobacco- and menthol-flavoured HTP sticks, TCC smoke data were obtained from reference-grade (3R4F, 1R6F) and Marlboro Red 100 cigarettes, ECIG aerosol data were obtained from tobacco-flavoured ECIG liquid using 1st- and 2nd-generation ECIG devices at 10 and 14 wattage.
| HPHC | HTP Aerosol | TCC Smoke | ECIG Aerosol |
|---|---|---|---|
| Nicotine (mg) | 0.5–1.5 | 0.7–2.1 | 0.07–1.73 |
| Total gas-phase radicals (pmol) | 12.5–12.6 | 567.6 | 5.3–47.8 |
| Non-polar | 13.9–14.3 | 449.9 | 2.4–19.2 |
| Polar | 6.8–8.2 | 9.6 | 5.9–43.3 |
| Carbonyls (µg) | |||
| Formaldehyde | 0.9–22.6 | 3.2–74.4 | 0.5–3.7 |
| Acetaldehyde | 128.5–301. 5 | 567.0–1534 | 0.8–2.9 |
| Acetone | 18.8–48.37 | 210–775.6 | - |
| Acrolein | 4.0–13.1 | 56.7–160.9 | 0.3–1.1 |
| Propionaldehyde | 9.6–22.3 | 48.4–124.0 | - |
| Crotonaldehyde | 1.4–6.4 | 10.10–65.7 | - |
| Methacrolein | 6.5 | 85.5 | - |
| Butyraldehyde | 14.9–30.7 | 22.2–65.0 | - |
| Valeraldehyde | 20.1 | - | - |
| Glyoxal | 3.1 | - | - |
| Methyl glyoxal | 33.5 | - | - |
| 2-Butanone | 4.2–6.5 | 11.0–220.5 | - |