Table 4.
List of harmful and potentially harmful constituents (HPHCs) reported to be more than two-fold higher in heated tobacco product mainstream aerosol (HTP aerosol) compared to mainstream smoke of traditional combustible cigarettes (TCC smoke) (adapted from St Helen et al., 2018) [20].
| HPHC | Fold Increase in HTP Aerosol Compared to TCC Smoke | |
|---|---|---|
| 1 | 1,4-Dioxane, 2-ethyl-5-methyl- | 137 |
| 2 | Hexadecanoic acid, ethyl ester | 60 |
| 3 | Trans-4-hydroxymethyl-2-methyl-1,3-dioxolane | 47 |
| 4 | Stearate, ethyl- | 24 |
| 5 | 12,14-Labdadiene-7,8-diol, (8a,12E) | 21 |
| 6 | Butylated hydroxytoluene | 18 |
| 7 | Ethyl linoleate | 16 |
| 8 | Labdane-8,15-diol, (13S) | 9 |
| 9 | Propylene glycol | 6 |
| 10 | 2-Furanmethanol | 4 |
| 11 | Butyrolactone | 5 |
| 12 | Methyl furoate | 4 |
| 13 | 2-Cyclopentene-1,4-dione | 4 |
| 14 | 2-Furanmethanol, 5-methyl- | 3 |
| 15 | Ethyl linolenate | 3 |
| 16 | 2-Methylcyclobutane-1,3-dione | 3 |
| 17 | Lanost-8-en-3-ol, 24-methylene-, (3beta) | 3 |
| 18 | 2-Furancarboxaldehyde, 5-methyl- | 3 |
| 19 | Eicosane, 2-methyl- | 3 |
| 20 | 1,2,3-Propanetriol, diacetate (diacetin) | 2 |
| 21 | Glycidol | 2 |
| 22 | Heneicosane, 2-methyl- | 2 |