Table 1.
Summary of the properties, functions, and therapeutic modalities of ICG nanocomposites.
| ICG Nanocomposites | |||||||
|---|---|---|---|---|---|---|---|
| Nanoplatforms | Functions | Types | Trigger | Target | Advantages | References | |
| ICG/MOFs | ZSZIT | H2S gas therapy | vivo | PH | Large surface area/Adjustable pore size and shape/Adjustable composition/Functionalised surface | [14] | |
| DI@HMONs-PMOF | PDT/PTT | vivo | PH/660/808 nm | [15] | |||
| DOX&ICG@H-PMOFm | CT/PTT/PDT&NIRF/PTI | vivo | PH/660&808 nm | [16] | |||
| ICG-PtMOFs@GNSs@HSA-Gd | PT/FL/MSOT/X-ray CT/MRI | vivo | PH | [18] | |||
| ZIF-ICG@ZIF-GOx@MPN | PTT/PDT/CDT | vivo | PH/NIR | [19] | |||
| Fe-DOX@Gd-MOF-ICG | MRI/PTI/PAI&PTT/PDT | vivo | PH/NIR | [20] | |||
| ICG/Polymer | FA-ICG-PLGA-lipid | FLI | vitro | NIR | Biodegradable | [24] | |
| DOX&ICG-PLGA-lecithin-PEG | CT/ PTT | vitro | NIR | [26] | |||
| ICG-PEG-PLL-PLLeu | FLI | vivo | NIR | Protection of enclosed drugs, high bioavailability, and good biocompatibility | [28] | ||
| Liposome-coated ICG | ICG -Lipid | PTT&Imaging | vivo | NIR | [29] | ||
| FAL-ICG-HAuNS | PDT/PTT | vivo | NIR | ER | [31] | ||
| Lipo-cyanine dyes | NIR-II Imaging | vitro | NIR-II | [32] | |||
| FA-ICG&DOX-Gd-Lipo | PT/CT&MRI/FL/PAI | vivo | NIR | FRa | [33] | ||
| ICG&Ce6&TPZ-Lipo | PTT/PDT | vivo | 660/808 nm | [34] | |||
| Lipo@ICG@CuS | PDT/PTT | vivo | NIR | [35] | |||
| ICG based Micelles Nanocomposites | Micelles -DOX & ICG | PTT/CT&NIR Imaging | vivo | PH/NIR/GSH | Nucleus/DNA Cleavage | Small size, Ease of assembly and versatility | [36] |
| ICG-NH2-PEG-PCC | PTT&NIR Imaging | vivo | NIR | [37] | |||
| GA-PEG-TK-ICG PMs | PTT/CT | vivo | NIR/ROS | HSP90 | [38] | ||
| ICG&PCL&5-FU&MEO2MA-b-HMAM | PTT/CT | vivo | NIR | [39] | |||
| ICG-HA-PTX | PTT/CT | vivo | NIR | CD44 | [40] | ||
| TMTP1-PEG-PLGA-ICG | CT&NIR-FL | vivo | NIR | T-SLN | [41] | ||
| ICG/Gold Composites | TNYL-ICG-HAuNS | PDT/PTT | vivo | NIR | Nrf2&NQO-1&HIF-1α | photothermal effect, porous mesoporous structure, uniform size | [45] |
| PNM@AuNC@ICG&DOX | PTT/Immunotherapy | vivo | NIR | Tumor-associated macrophage/neutrophil/Natural killer cell&CD44/VCAM-1/LFA-1 | [46] | ||
| MPLA & ICG-AUNCs | PTT/PDT | vivo | NIR | Tumor-associated antigen | [47] | ||
| DOX/ICG@biotin-PEG-AuNC-PCM | PDT/CT | vivo | NIR | Endocytosis | [48] | ||
| GNB@SiO2-ICG | PTT&FLI/PAI | vivo | NIR | [49] | |||
| ICG based multifunctional Composites | GNS@CaCO3/ICG | PT&FL Imaging | vivo | PH/NIR | Acid degradation, Immunomodulation | [52] | |
| Fe3O4@PDA@CaCO3/ICG | PDT/PTT | vivo | PH/NIR | [53] | |||
| Mn@CaCO3/ICG-siRNA | PDT/Immunotherapy | vivo | PH/NIR | PD-L1 | [54] | ||
| ALE/Man-g-HA | PDT/PTT | vivo | PH/NIR | CD44 | [55] | ||