Table 3.
Pharmacokinetic plasma parameters of perillyl acid, following oral administration of a single dose of 500 mg/kg of free POH and POH-loaded NLCs.
| Parameter | Free POH | POH-Loaded NLCs |
|---|---|---|
| Cmax (ng.mL−1) | 40,507.18 | 43,552.17 |
| Tmax (h) | 1 | 4 |
| AUC0–24h (ng.h/mL) | 322,833.78 | 598,139.18 |
| T½ (h) | 8.65 | 11.90 |
| Kel (1/h) | 0.080 | 0.058 |
| Cl (L/h) | 0.0015 | 0.0008 |
| Vd (L) | 0.0193 | 0.0143 |
Cmax: maximum concentration; Tmax: time to reach maximum concentration; AUC0–24h: area under the plasma concentration–time curve; T1/2: half-life; Kel: elimination rate constant; Vd: apparent volume of distribution; Cl: clearance.