Table 4.
Pharmacokinetic tissues parameters of perillyl acid, following oral administration of a single dose of 500 mg/kg of free POH and POH-loaded NLCs.
| Treatment | Tissue | Cmax (ng.mL−1) | Tmax (h) | AUC0–24h (ng.h/mL) | T½ (h) | Kel (1/h) |
|---|---|---|---|---|---|---|
| Brain | 7694.15 | 2 | 72,104.51 | 6.40 | 0.108 | |
| Lung | 41,265.63 | 2 | 442,244.37 | 8.63 | 0.080 | |
| Free POH | Kidney | 34,245.26 | 2 | 437,725.63 | 12.92 | 0.053 |
| Liver | 40,490.68 | 4 | 678,190.26 | 29.11 | 0.023 | |
| Spleen | 13,022.72 | 4 | 225,678.26 | 8.68 | 0.079 | |
| Brain | 16,085.07 | 2 | 263,771.20 | 19.35 | 0.035 | |
| Lung | 19,067.11 | 1 | 192,494.69 | 12.15 | 0.057 | |
| POH-loaded NLCs | Kidney | 23,873.44 | 1 | 228,540.18 | 10.10 | 0.068 |
| Liver | 28,884.92 | 2 | 320,092.07 | 19.74 | 0.035 | |
| Spleen | 10,662.32 | 1 | 75,687.80 | 5.52 | 0.125 |
Cmax: maximum concentration; Tmax: time to reach maximum concentration; AUC0–24h: area under the tissue concentration–time curve; T1/2: half-life; Kel: elimination rate.