Table 8.

Major active compounds of four core herbs.

Molecule Number	Molecule Name	Chemical Structure	ADME Evaluation
			Lipsinski	Ghose	Veber	Egan	Muegge
1	Dihydrochelerythrine		Yes	Yes	Yes	Yes	Yes
2	Sitogluside		Yes	No	Yes	Yes	No
3	Glycyrol		Yes	Yes	Yes	Yes	Yes
4	Hesperetin		Yes	Yes	Yes	Yes	Yes
5	Salutaridine		Yes	Yes	Yes	Yes	Yes
6	indirubin		Yes	Yes	Yes	Yes	Yes
7	qingdainone		Yes	Yes	Yes	Yes	Yes
8	indigo		Yes	Yes	Yes	Yes	Yes
9	Quindoline		Yes	Yes	Yes	Yes	Yes
10	Indicaxanthin		Yes	No	Yes	Yes	Yes
11	Paeoniflorgenin		Yes	Yes	Yes	Yes	Yes
12	6-Deglucosyl-3-O-methylpaeoniflorin		Yes	Yes	Yes	Yes	Yes
13	(2R,3R)-2-(3,5-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one		Yes	Yes	Yes	Yes	Yes
14	Columbianetin acetate		Yes	Yes	Yes	Yes	Yes
15	Cianidanol		Yes	Yes	Yes	Yes	Yes
16	Triptolide		Yes	Yes	Yes	Yes	Yes
17	quercetin		Yes	Yes	Yes	Yes	Yes
18	5-[5-(4-Methoxy-phenyl)-furan-2-ylmethylene]-pyrimidine-2,4,6-trione		Yes	Yes	Yes	Yes	Yes
19	kaempferol		Yes	Yes	Yes	Yes	Yes
20	Sugiol		Yes	Yes	Yes	Yes	No
21	Imperatorin		Yes	Yes	Yes	Yes	Yes
22	Palmitoleic acid		Yes	Yes	No	Yes	No

ADME: absorption, distribution, metabolism, and excretion.