Table 2.

Univariate linear mixed effect analysis of variables associated with CBD trough concentrations.

Variable	Estimate (β)	Standard Error	p-Value
Levothyroxine	1.40	0.2485	<0.01
Sulthiame	1.42	0.2598	0.02
Clobazam	1.42	0.3591	0.03
Ketogenic diet	1.51	0.2443	<0.01
Food administration	1.34	0.5274	0.02

Levothyroxine, sulthiame, and clobazam median (range) dose was 50.0 µg/day (37.5–100.0), 400 mg/day (200–600), and 20 mg/day (10–30), respectively. In the model, ketogenic diet or food administration took the value of 1 or 0 if the patient was co-treated with ketogenic diet or whether or not food was provided concomitantly to CBD (one hour previous or after CBD administration), respectively.