Table 3.

Multivariate linear mixed effect analysis of variables associated with CBD trough concentrations.

Variable	Estimate (β)	Standard Error	p-Value
Intercept	−2.42	1.0779	0.03
lnD	1.15	0.2201	<0.001
Levothyroxine	0.74	0.1649	<0.001
Food administration	0.45	0.1550	0.009
Ketogenic diet	0.77	0.3141	0.02

The final model is described by the following equation: ln(C0) = −2.42 + 1.15 × ln (D) + 0.74 × levothyroxine + 0.45 × food administration + 0.77 × ketogenic diet + (1|ID), in which ID means subject and D means dose. Levothyroxine, food administration, and ketogenic diet can take the value of 1 or 0 if the patient was co-treated with the hormone thyroid, if the drug or food was provided concomitantly to CBD, and if the patient was under ketogenic diet treatment or not, respectively.