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Main steps related to aspartame discovery, approval, development, and use, along with some of the clinical trials, in vivo and in vitro studies evidencing its biological effects (more details in Table A1), and the dynamics of publications describing them [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59].
