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. 2023 Aug 10;15(8):2121. doi: 10.3390/pharmaceutics15082121

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of calix[4]arene vectors efficiency for the delivery of PNA. (A,C) Percentage of fluorescence positive cells in U251 glioma (A) or HT29 colon cancer cell line (C) transfected with an octaarginine functionalized PNA (R8-PNA) or unfunctionalized PNA (naked PNA) used alone or delivered by different calix[4]arene vectors. (B,D) Percentage of fluorescence-positive cells obtained comparing three different batches (Arg-Hex A–C) of the same vector (the lead compound Arg-Hex) obtained by three different purification strategies. Results are resented as mean ± S.E.M; statistical differences between groups were compared using a one-way repeated-measures ANOVA. * p < 0.05, ** p < 0.01.