Table 10.
Compounds 5(a–l) cytotoxic potency values by using MTT assay against HepG-2, U937 and SKOV3 cell lines.
| Tested Target | IC50 (μg/mL) | ||
|---|---|---|---|
| HepG-2 | U937 | SKOV3 | |
| Etoposide | 2.02 ± 0.15 | 5.23 ± 3.01 | 6.81 ± 1.56 |
| 5a | 65.16 ± 1.45 | 101.49 ± 1.09 | 119.45 ± 1.35 |
| 5b | 86.32 ± 1.05 | 123.01 ± 1.65 | 160.23 ± 1.41 |
| 5c | 128.71 ± 1.30 | >200 | >200 |
| 5d | 57.45 ± 0.95 | 74.20 ± 2.01 | 88.14 ± 2.20 |
| 5e | 147.26 ± 1.01 | 168.71 ± 2.11 | >200 |
| 5f | 42.11 ± 2.11 | 60.12 ± 2.61 | 75.43 ± 0.99 |
| 5g | 71.94 ± 0.54 | >200 | >200 |
| 5h | 29.56 ± 1.20 | 36.05 ± 1.00 | 51.25 ± 0.22 |
| 5i | 112.55 ± 2.46 | 131.33 ± 1.05 | >200 |
| 5j | 84.46 ± 0.89 | 117.46 ± 1.19 | 129.50 ± 2.30 |
| 5k | 59.78 ± 1.12 | 83.12 ± 3.46 | 95.09 ± 2.14 |
| 5l | 80.28 ± 3.01 | 110.51 ± 0.51 | 124.13 ± 1.02 |