Table 4.
Comparison of characteristics of CRRT in children according to weight (< 5 kg versus 5–10 kg)
| Data | ≤ 5 kg (N = 25) | 5–10 kg (N = 26) | P value | ||
|---|---|---|---|---|---|
| Key indication for CRRT, n (%) | |||||
|
Renal failure ALF High ammonia High lactate Fluid overload Multiple reasons |
19 (76) 12 (48) 8 (32) 8 (32) 13 (52) 18 (72) |
15 (57.7) 15 (57.7) 5 (19.2) 11 (42.3) 8 (30.8) 16 (61.5) |
0.166 0.488 0.296 0.447 0.124 0.428 |
||
| Primary diagnosis, n (%) | |||||
| Acute liver failure | 13 (52) | 11 (42.3) | 0.488 | ||
| Chronic liver disease/biliary atresia | 1 (4) | 11 (42.3) | 0.001 | ||
|
Sepsis Inborn error of metabolism Other *Some patients had multiple primary diagnoses |
6 (24) 6 (24) 12 (48) |
6 (23.1) 8 (30.8) 8 (30.8) |
0.938 0.588 0.208 |
||
| CRRT catheter site, n (%) | |||||
|
Femoral vein Internal jugular vein Subclavian vein |
3 (12) 20 (80) 2 (8) |
5 (19.23) 19 (73.08) 2 (7.69) |
0.883 | ||
| CRRT catheter size, n (%) | |||||
|
6F 6.5F 8F 10F |
1 (3.85) 24 (96) 0 0 |
0 18 (69.2) 7 (26.9) 1 (4) |
0.008 | ||
| Blood flow rate (mL/kg/min)* | 14.29 | (11.36,17.80) | 8.60 | (7.14,10.80) | < 0.01 |
| Filters per patient* | 5 | (3,16) | 8 | (5,21) | < 0.01 |
| Reason for circuit change, n (%) | |||||
|
Elective change Filter issue Vascath issue Multiple reasons |
55 26 5 4 |
(61.11%) (28.89%) (5.56%) (4.44%) |
67 45 18 3 |
(50.38%) (33.83%) (13.53%.) (2.26%) |
0.128 |
| Filter Life (hrs.)* | 52 | (35,71) | 38 | (19,64) | 0.002 |
| CRRT dose* | 60 | (52,80) | 60 | (45,66) | 0.138 |
| Survival (n (%)) | 9 | (36.0) | 18 (69.2) | 0.025 | |
Bold denotes p<0.05
*Median (IQR 25%, 75%); N (%)