Table 6.
Comparison of characteristics of Continuous Renal Replacement Therapy in children according to survival status
| Data | Survivors (N = 27) | Non-survivors (N = 24) | P value | ||
|---|---|---|---|---|---|
| Hours of CRRT (Effective)a | 120 | (70, 384) | 64.5 | (16, 210) | 0.045 |
| Mean Filter life per Individual (hrs)b | 43.48 | ± 20.58 | 37.25 | ± 22.92 | 0.311 |
| CRRT catheter site, n (%) | |||||
|
Femoral vein (15.6%) Internal jugular vein (76.4%) Subclavian vein (7.84%) |
6 21 0 |
(22.2) (77.7) (0) |
2 18 4 |
(8.3) (75) (16.6) |
0.048 |
| CRRT catheter size, n (%) | |||||
|
6F (1.96%) 6.5F (82.35%) 8F (13.73%) 10F (1.96%) |
1 21 4 1 |
(3.7) (77.7) (14.8) (3.7) |
0 21 3 0 |
(87.5) (12.5) |
1.000 |
| Blood flow rate (mL/kg/min)a | 8.80 | (7.69, 12.50) | 13.6 | (7.71, 17.83) | 0.054 |
| CRRT dose (mL/kg/h)a | 60 | (51.5, 79) | 60 | (47, 66) | 0.675 |
| Anticoagulation, n (%) | |||||
|
Prostacyclin Heparin |
26 1 |
(96.3) (3.7) |
20 0 |
(83.3) (0) |
|
| No anticoagulant | 0 | (0) | 4 | (16.67) | 0.043 |
| Serum creatinine, μmol/La | 51 | (27, 170) | 55.5 | (38,89) | 0.25 |
| Serum urea, mmol/La | 7.9 | (5.4, 13.0) | 6.75 | (3.8, 17.2) | 0.463 |
| Base excess, mEq/Lb | -5.33 | ± 7.21 | -6.44 | ± 9.65 | 0.64 |
| Serum lactate, mmol/La | 4.5 | (1.5, 7.8) | 5.6 | (2.61, 10.66) | 0.183 |
| Serum bicarbonate, mmol/La | 20.90 | ± 6.43 | 20.84 | ± 8.40 | 0.982 |
| Key indication for CRRT, n (%) | |||||
|
Renal failure ALF High ammonia High lactate Fluid overload > 10% Multiple reasons |
19 (70.4) 13 (48.1) 4 (14.8) 9 (33.3) 9 (33.3) 16 (59.3) |
15 (62.5) 14 (58.3) 9 (37.5) 10 (41.7) 12 (50.0) 18 (75.0) |
0.552 0.467 0.064 0.539 0.227 0.234 |
||
| Primary diagnosis, n (%) | |||||
| Acute liver failure | 10 (37.0) | 14 (58.3) | 0.128 | ||
| Chronic liver disease/biliary atresia | 7 (25.9) | 5 (20.8) | 0.669 | ||
| Sepsis | 4 (14.8) | 8 (33.3) | 0.120 | ||
| Inborn error of metabolism | 7 (25.9) | 7 (29.2) | 0.796 | ||
| Other | 10 (37.0) | 10 (41.7) | 0.735 | ||
| *Some patients had multiple primary diagnoses | |||||
Bold denotes p<0.05
aMedian (IQR 25%, 75%)
bMean (SD)