Table 2.

Odds ratio (OR) of clinical and functional measures associated with the use of different types of substance estimated from multivariate logistic regression

Use (vs. non-use) of		UHR		FEP
	Predictor	OR (95% CI)	p-value	OR (95% CI)	p-value
Any illicit substance	BPRS-psychosis	1.05 (0.99–1.11)	0.1	1.06 (1.02–1.11)	0.008
	BPRS- negative	0.90 (0.82–0.98)	0.022	0.92 (0.86–0.99)	0.028
	K10	1.01 (0.99–1.04)	0.2	1.02 (1.00–1.04)	0.1
	SOFAS	0.99 (0.97–1.01)	0.3	1.01 (0.99–1.02)	0.2
ATS	BPRS-psychosis	1.06 (0.98–1.14)	0.2	1.07 (1.02–1.12)	0.004
	BPRS- negative	0.87 (0.76–0.99)	0.036	0.92 (0.86–1.00)	0.039
	K10	1.01 (0.98–1.04)	0.6	1.01 (0.99–1.03)	0.4
	SOFAS	0.99 (0.97–1.01)	0.5	0.99 (0.98–1.01)	0.3
Cannabis	BPRS-psychosis	1.05 (1.00–1.12)	0.07	1.05 (1.01–1.10)	0.025
	BPRS- negative	0.90 (0.83–0.99)	0.025	0.94 (0.88–1.01)	0.1
	K10	1.01 (0.99–1.03)	0.2	1.01 (0.99–1.03)	0.2
	SOFAS	0.99 (0.98–1.01)	0.4	1.01 (0.99–1.02)	0.3
Tobacco	BPRS-psychosis	1.05 (0.99–1.11)	0.1	1.05 (1.00–1.09)	0.05
	BPRS- negative	0.92 (0.84–1.01)	0.07	0.92 (0.87–0.98)	0.01
	K10	1.01 (0.99–1.04)	0.3	1.00 (0.98–1.02)	0.8
	SOFAS	1.00 (0.98–1.01)	0.7	0.99 (0.98–1.01)	0.3

P values in bold signify a statistically significant difference

Odds ratio (OR) of substance use (dependent variable) associated with one unit increase in clinical and functional measures (independent variable) estimated from multivariate logistic regression model controlling for confounding factors including age, gender, sexual orientation, Aboriginal and Torres Strait Islander (ATSI), and culturally and linguistically diverse (CALD) status. Missing data were imputed via MICE using 20 imputed datasets

^aillicit substance includes cannabis, amphetamine-type stimulants (ATS), cocaine, hallucinogens, and opioids (i.e. does not include the non-medicinal use of pharmaceuticals)