Table 4.
HRs and 95% CIs for small intestinal cancer risk in relation to fibre, fat and its sub-groups
| Small intestinal cancer (n = 160) | Adenocarcinoma (n = 51) | Carcinoid tumour (n = 62) | ||||
|---|---|---|---|---|---|---|
| Univariable model HR (95% CI) | Multivariable modela HR (95% CI) | Univariable model HR (95% CI) | Multivariable modela HR (95% CI) | Univariable model HR (95% CI) | Multivariable modela HR (95% CI) | |
| Fibre (g/1000 kcal) | ||||||
| T1 (≤ 9.7) | Ref | Ref | Ref | Ref | Ref | Ref |
| T2 (> 9.7, ≤ 12.2) | 1.03 (0.72–1.48) | 1.15 (0.79–1.68) | 0.69 (0.35–1.37) | 0.78 (0.39–1.57) | 0.96 (0.53–1.74) | 1.09 (0.59–2.03) |
| T3 (> 12.2, ≤ 47.8) | 0.78 (0.51–1.17) | 0.93 (0.60–1.44) | 0.78 (0.40–1.54) | 0.94 (0.46–1.95) | 0.84 (0.44–1.60) | 1.06 (0.53–2.11) |
| p trend | 0.22 | 0.74 | 0.49 | 0.88 | 0.59 | 0.87 |
| Continuous (10 g/1000 kcal) | 0.77 (0.46–1.31) | 1.05 (0.61–1.82) | 0.71 (0.28–1.78) | 0.94 (0.36–2.46) | 0.74 (0.32–1.72) | 1.08 (0.44–2.63) |
| Total fat (g/1000 kcal) | ||||||
| T1 (≤ 35.7) | Ref | Ref | Ref | Ref | Ref | Ref |
| T2 (> 35.7, ≤ 41.1) | 0.57 (0.38–0.84) | 0.55 (0.37–0.81) | 0.45 (0.22–0.93) | 0.44 (0.22–0.91) | 0.46 (0.23–0.91) | 0.44 (0.22–0.87) |
| T3 (> 41.1, ≤ 80.9) | 0.76 (0.53–1.09) | 0.72 (0.50–1.05) | 0.65 (0.34–1.23) | 0.63 (0.32–1.22) | 0.90 (0.51–1.58) | 0.84 (0.47–1.51) |
| p trend | 0.12 | 0.07 | 0.15 | 0.14 | 0.69 | 0.54 |
| Continuous (10 g/1000 kcal) | 0.91 (0.72–1.16) | 0.88 (0.68–1.13) | 0.94 (0.62–1.44) | 0.93 (0.60–1.45) | 0.97 (0.66–1.43) | 0.91 (0.61–1.37) |
| Saturated fat (g/1000 kcal) | ||||||
| T1 (≤ 13.3) | Ref | Ref | Ref | Ref | Ref | Ref |
| T2 (> 13.3, ≤ 16.3) | 1.00 (0.67–1.48) | 0.87 (0.58–1.31) | 0.72 (0.36–1.43) | 0.56 (0.28–1.14) | 1.16 (0.61–2.21) | 0.99 (0.51–1.93) |
| T3 (> 16.3, ≤ 43) | 1.14 (0.78–1.66) | 0.95 (0.63–1.44) | 0.87 (0.45–1.66) | 0.61 (0.30–1.23) | 1.37 (0.74–2.54) | 1.12 (0.57–2.21) |
| p trend | 0.50 | 0.85 | 0.67 | 0.19 | 0.32 | 0.72 |
| Continuous (10 g/1000 kcal) | 1.17 (0.77–1.76) | 0.93 (0.58–1.49) | 1.37 (0.67–2.84) | 1.00 (0.44–2.28) | 1.28 (0.66–2.49) | 0.96 (0.45–2.05) |
| Monounsaturated fat (g/1000 kcal) | ||||||
| T1 (≤ 12.1) | Ref | Ref | Ref | Ref | Ref | Ref |
| T2 (> 12.1, ≤ 14.6) | 0.68 (0.46–1.01) | 0.63 (0.42–0.93) | 0.58 (0.30–1.14) | 0.56 (0.28–1.10) | 0.83 (0.44–1.56) | 0.74 (0.39–1.41) |
| T3 (> 14.6, ≤ 44.2) | 0.78 (0.54–1.14) | 0.72 (0.47–1.10) | 0.59 (0.30–1.16) | 0.60 (0.28–1.29) | 1.04 (0.57–1.90) | 0.99 (0.51–1.94) |
| p trend | 0.24 | 0.14 | 0.13 | 0.18 | 0.84 | 0.97 |
| Continuous (10 g/1000 kcal) | 0.84 (0.52–1.35) | 0.79 (0.43–1.43) | 0.69 (0.28–1.66) | 0.84 (0.28–2.50) | 1.01 (0.48–2.13) | 1.03 (0.40–2.69) |
| Polyunsaturated fat (g/1000 kcal) | ||||||
| T1 (≤ 5.3) | Ref | Ref | Ref | Ref | Ref | Ref |
| T2 (> 5.3, ≤ 6.98) | 0.98 (0.69–1.41) | 0.91 (0.62–1.32) | 0.76 (0.40–1.46) | 0.71 (0.36–1.40) | 0.95 (0.54–1.67) | 0.83 (0.46–1.49) |
| T3 (> 6.98, ≤ 38) | 0.70 (0.47–1.04) | 0.72 (0.47–1.11) | 0.70 (0.35–1.38) | 0.72 (0.35–1.50) | 0.61 (0.32–1.18) | 0.61 (0.31–1.23) |
| p trend | 0.07 | 0.13 | 0.31 | 0.41 | 0.14 | 0.17 |
| Continuous (10 g/1000 kcal) | 0.40 (0.18–0.90) | 0.44 (0.17–1.10) | 0.51 (0.13–2.08) | 0.60 (0.12–2.96) | 0.35 (0.09–1.33) | 0.35 (0.08–1.67) |
HR hazard ratio, 95% CI 95% confidence interval, Ref reference category
aAdjusted for energy, stratified by age, sex and country