Table 3.
Outcomes studied and comparison between groups who received platelet transfusions from different platelet count thresholds or different numbers of platelet transfusions
| Author, year | N | n |
Mortality n (%) |
IVH n (%) |
Other hemorrhage n (%) |
Sepsis n (%) |
NEC n (%) |
Findings | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 | G2 | G1 | G2 | G1 | G2 | G1 | G2 | G1 | G2 | G1 | G2 | |||
|
Garcia 2001 |
61 | 54 | 7 | 12 (22.2) | 3 (42.9) | 21 (38.9) |
4 (57.1) |
- | - | 24 (44.4) |
4 (57.1) |
10 (18.5) |
0 (0.0) |
No association between the increasing number of PTx given and mortality |
| Del Vecchio 2001 [31] | 114 | 59 | 55 | † | † | - | - | - | - | - | - | - | - | Significant increase in mortality rate in infants who received > 4 PTx vs. those who received 1 PTx (RR 2.9; p < 0.0001). Significant increase in infants who received 1 PTx vs. all the other infants in the NICU who did not receive any (RR 10.4; p < 0.0001) |
| von Lindern 2012 [24] | 679 | 326 | 353 | 22 (6.7) | 25 (7.1) | 63 (19.5) a | 75 (22.7) a | - | - | 98 (30.1) | 89(25.2) | 9(2.8) | 14(4.0) | No significant difference in the incidence of IVH between liberal and restrictive transfusion groups (p = 0.31) |
|
Curley 2019 |
660 | 329b | 331b |
G1: 85(26.2)c G2: 61 (18.5)c |
181(55.9) | 175(53.7)d | 42(13.0) | 54 (16.6)d |
Significant increase in mortality and major bleeding in preterm infants in the liberal transfusion group vs. restrictive group (OR 1.57; 95%CI 1.06 -2.32; p = 0.02) No significant differences in sepsis and NEC between groups |
|||||
| Kumar 2019 [28] | 44 | 22 | 22 | 8 (36.4) |
9 (40.9) |
9 (40.9) |
2 (9.1) |
- | - |
8 (36.3) |
2 (9.1) |
- | - |
Significant association between liberal transfusion and any grade of IVH vs. restrictive transfusion (p = 0.034) No significant differences between liberal and restrictive transfusion groups in grade III or IV IVH or mortality |
n number of infants, IVH Intraventricular Hemorrhage, NEC Necrotizing Enterocolitis, G1 Group 1, G2 Group 2, PTx Platelet Transfusion, RR relative Risk, NICU Neonatal Intensive Care Unit, OR, Odds Ratio, CI Confidence Interval, -, outcomes not studied, † outcome studied but unavailable number and percentage of infants who developed the outcome
aPercentage calculated for a total number of infants who had a cranial ultrasound scan: 323 infants in group 1 and 330 in group 2
b5 infants in group 1 and 2 infants in group 2 did not have primary outcomes reported and were excluded in the phase of outcomes analysis due to palliative care (3); randomization error (2); and issues with consenting process (2): Group 1, 324; Group 2, 329
cDeath and major bleeding were accessed together, as the primary outcome of the study
dPercentage calculated for a total number of 326 infants in group 2