Fig. 2.

Change in mean EASI score, mean Peak Pruritus NRS score, and mean CDLQI score from baseline to week 16 (FAS and IGA > 1 subgroup). The color scale graphic displays the changes in absolute values from baseline (red) to week 16 (blue) for each outcome. EASI ranges from < 2 (clear/almost clear) to 2 to < 7 (mild), 7 to < 21 (moderate), 21 to < 50 (severe), and ≥ 50 (very severe). CDLQI ranges from 0 to 1 (no effect) to 2–6 (small effect), 7–12 (moderate effect), 13–18 (very large effect), and 19–30 (extremely large effect). Peak Pruritus NRS ranges from 0 (no itch, green zone) to 10 (worst itch imaginable, orange zone). Severity bands are based on validated published scales [21, 26–29]. CDLQI Children’s Dermatology Life Quality Index, EASI Eczema Area and Severity Index, FAS full analysis set, IGA Investigator’s Global Assessment, NRS numerical rating scale, q2w every 2 weeks, q4w every 4 weeks, TCS topical corticosteroids