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. 2023 Aug 26;14:5224. doi: 10.1038/s41467-023-41049-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Single variant exposure plasma samples were collected, either from unvaccinated individuals after first infection with ancestral virus (n = 5), alpha (n = 10), beta (n = 4), delta (n = 7), BA.1 (n = 16), BA.2 (n = 12), BA.5 (n = 1), or CK.2.1.1 (n = 2) variant or from two (BNT/BNT, n = 6) or three-dose (BNT/BNT/BNT, n = 6) vaccinated (ancestral) individuals. Titers of neutralizing antibodies against BA.2.75 variants (CB.1, BR.3, CH.1.1), BA.5 variants (BA.5.2.1, BE.1.1, BF.7, BQ.1.3, BQ.1.1, BQ.1.18), recombinant XBB variants (XBB.1, XBB.1.5.1), or recombinant XBF.3 for individual patients (circles) and geometric mean (red line) are shown. Titers below 16 were treated as negative (dotted line), and titers below 1 were set to 1. BNT = BNT162b2, IC₅₀ titer = 50% neutralization titer.