Skip to main content
. 2023 Aug 26;14(8):568. doi: 10.1038/s41419-023-06084-5

Fig. 6. Upregulation of DDUP confers carboplatin resistance to ovarian cancer in vivo.

Fig. 6

A, B PDOVCs#1 stably expressing DDUP/WT or DDUP/mutant were subcutaneously inoculated into immunodeficient mice, following treatment with carboplatin (50 mg/kg) alone or carboplatin ((50 mg/kg) plus Berzosertib (60 mg/kg). Six mice were randomly assigned to each group. A Representative images of xenograft tumors and results of IHC and TUNEL staining. B Quantification of the weights of the xenograft tumors, DDUP, γ-H2AX, and Ki-67 staining, and the apoptotic index of the xenograft tumors treated with the indicated chemotherapy agents. The error bars represent the mean ± SD of data from three independent experiments; *P < 0.05, **P < 0.01, ***P < 0.001.