Figure 6.

Stable connectivity signatures and most distinctive edges during identification in MS patients. (A) Circle plots are arranged symmetrically, with the left half representing regions from the left hemisphere. Red lines indicate the 99.5th percentile of distinctive edges, i.e., connections that ranked highest in similarity and which consistently – averaged over all subjects – yielded the smallest difference between source and target session. The yellow-shaded circle plot shows the connection signatures averaged over all intervals. Generally, intra-hemispheric connections between and within the FPN and DMN a highly represented. Unimodal resting-state networks such as VN or SMN are consistently less distinctive. (B) The number of distinctive edges split by different resting-state networks. DMN, FPN and SN consistently connect with more distinctive edges than all other networks. In grey, results from permutation are overlaid, showing significantly higher numbers of distinctive edges in DMN, FPN and SN, as well as significantly lower numbers in all other networks . No shift in network importance occurred during the 4 years of observation. (C) Visualization of the stability of single edges. Edges are visualized according to their frequency of appearance in different intervals. The leftmost circle plot visualizes edges that are amongst the 99.5th percentile of most distinctive edges in one interval, the rightmost plot visualizes those edges that are amongst the 99.5th percentile of most distinctive edges in all five intervals. The bar plot below visualizes the distribution split by resting-state network.