Table 3.
Chi-Square Test Results in Allele and Genotype Model of SNPs in Different Stratification Analysis
| Stratification | SNP | Gene | Model | Genotype | Case | Control | Chi Score | OR (95% CI) | p | OR (95% CI) | p-Adjusted |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Neurological vs Myxedema | rs2277923 | NKX2-5 | Genotype | C/C | 9 | 26 | 9.991 | 0.006769 | 0.008253 | ||
| T/C | 3 | 65 | |||||||||
| T/T | 7 | 49 | |||||||||
| Dominant | C/C, T/C | 12 | 91 | 0.02488 | 0.9231 (0.3414–2.496) | 0.8747 | 0.9231 (0.3414–2.496) | 1 | |||
| T/T | 7 | 49 | |||||||||
| Recessive | C/C | 9 | 26 | 8.081 | 3.946 (1.457–10.69) | 0.004472 | 3.946 (1.457–10.69) | 0.01451 | |||
| T/T, T/C | 10 | 114 | |||||||||
| Allele | C | 21 | 117 | 2.474 | 1.721 (0.87–3.404) | 0.1157 | 1.721 (0.87–3.404) | 0.1207 | |||
| T | 17 | 163 | |||||||||
| Mixed type vs Neurological | rs2234919 | TSHR | Genotype | A/A | 0 | 0 | 4.333 | 0.03738 | 0.0723 | ||
| C/A | 1 | 5 | |||||||||
| C/C | 23 | 14 | |||||||||
| Dominant | A/A, C/A | 1 | 5 | 4.333 | 0.1217 (0.01286–1.152) | 0.03738 | 0.1217 (0.01286–1.152) | 0.0723 | |||
| C/C | 23 | 14 | |||||||||
| Recessive | A/A | 0 | 0 | NA | NA (NA-NA) | NA | NA (NA-NA) | 1 | |||
| C/C, C/A | 24 | 19 | |||||||||
| Allele | A | 1 | 5 | 4.008 | 0.1404 (0.01567–1.258) | 0.04528 | 0.1404 (0.01567–1.258) | 0.08322 | |||
| C | 47 | 33 | |||||||||
| Mixed type vs Myxedema | R450H | TSHR | Genotype | A/A | 0 | 0 | 5.869 | 0.01541 | 0.1463 | ||
| G/A | 1 | 0 | |||||||||
| G/G | 23 | 140 | |||||||||
| Dominant | A/A, G/A | 1 | 0 | 5.869 | NA (NA-NA) | 0.01541 | NA (NA-NA) | 0.1463 | |||
| G/G | 23 | 140 | |||||||||
| Recessive | A/A | 0 | 0 | NA | NA (NA-NA) | NA | NA (NA-NA) | 1 | |||
| G/G, G/A | 24 | 140 | |||||||||
| Allele | A | 1 | 0 | 5.851 | NA (NA-NA) | 0.01557 | NA (NA-NA) | 0.1463 | |||
| G | 47 | 280 |
Note: Bold and italicized text indicates P<0.05.