Table 2.

Subdistribution hazard ratios (SHR) of distant metastasis and other cause mortality in women with non-metastatic breast cancer treated with PET, dependent on age, geriatric characteristics and comorbidity

	Distant metastatasis - SHR (95% CI)			Competing event - SHR (95% CI)
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3
Age
65–79 years	1.00 (ref)	1.00 (ref)	na	1.00 (ref)	1.00 (ref)	n/a
≥80 years	0.46 (0.16–1.31)	0.39 (0.14–1.12)	n/a	2.52 (1.83–3.46)	2.39 (1.70–3.34)	n/a
Geriatric characteristics
No walking impairment	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
Walking impairment	0.95 (0.21–4.24)	0.93 (0.20–4.27)	1.10 (0.22–5.56)	1.74 (1.22–2.50)	1.72 (1.17–2.53)	1.58 (1.07–2.33)
No cognitive impairment	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
Cognitive impairment	0.43 (0.06–3.28)	0.45 (0.06–3.59)	0.57 (0.06–5.05)	2.15 (1.47–3.15)	2.09 (1.42–3.06)	1.87 (1.30–2.68)
<5 medications per dag	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
≥5 medications per day	1.67 (0.46–6.05)	1.76 (0.47–6.64)	2.09 (0.55–7.94)	1.52 (1.05–2.22)	1.43 (0.96–2.11)	1.24 (0.81–1.90)
No sensory impairment	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
Sensory impairment	0.73 (0.16–3.31)	0.78 (0.17–3.63)	0.93 (0.75)	1.60 (1.15–2.24)	1.51 (1.07–2.13)	1.34 (0.95–1.90)
Total geriatric characteristics 0	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
Total geriatric characteristics ≥ 1	0.79 (0.26–2.37)	0.81 (0.25–2.61)	1.05 (0.31–3.54)	2.06 (1.55–2.74)	1.97 (1.46–2.63)	1.66 (1.23–2.25)
Comorbidities
0–1 comorbidities	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)	1.00 (ref)
≥2 comorbidities	0.76 (0.25–2.27)	0.74 (0.24–2.28)	0.88 (0.24–3.21)	1.72 (1.31–2.28)	1.60 (1.20–2.12)	1.47 (1.11–1.96)
Age/geriatric characteristics
65–79 years and 0 geriatric characteristics	1.00 (ref)	1.00 (ref)	n/a	1.00 (ref)	1.00 (ref)	n/a
65–79 years and ≥ 1 geriatric characteristics	0.83 (0.10–7.03)	0.91 (0.19–8.48)	n/a	2.60 (1.21–5.60)	2.46 (1.16–5.22)	n/a
>80 years and 0 geriatric characteristics	0.40 (0.10–1.60)	0.34 (0.08–1.37)	n/a	2.44 (1.68–3.56)	2.32 (1.56–3.45)	n/a
>80 years and ≥ 1 geriatric characteristics	0.49 (0.14–1.72)	0.43 (0.11–1.65)	n/a	3.51 (2.41–5.12)	3.35 (2.24–5.01)	n/a
Age/comorbidities
65–79 years and 0–1 comorbidities	1.00 (ref)	1.00 (ref)	n/a	1.00 (ref)	1.00 (ref)	n/a
65–79 years and ≥ 2 comorbidities	1.10 (0.21–5.67)	0.98 (0.16–5.99)	n/a	1.87 (1.03–3.39)	1.76 (0.95–3.26)	n/a
>80 years and 0–1 comorbidities	0.53 (0.14–1.97)	0.44 (0.12–1.60)	n/a	2.59 (1.75–3.83)	2.49 (1.63–3.80)	n/a
>80 years and ≥ 2 comorbidities	0.41 (0.10–1.71)	0.34 (0.08–1.52)	n/a	3.54 (2.37–5.29)	3.11 (2.14–5.12)	n/a

SHR: subdistribution hazard ratio. 95% CI: 95% confidence interval. Ref: reference. N/a: not applicable. Fine and Gray analyses: model 1 - crude model; model 2 - as model 1 plus TNM stage; model 3 - as model 2 plus age