Table 2.
MIBC subtypes and their typical molecular features
| LumP | LumNS | LumU | Stroma-rich | Ba/sq | Ne-like | |
|---|---|---|---|---|---|---|
| Differentiation | Luminal | Luminal | Luminal | Luminal and basal | Basal and squamous | Neuroendocrine |
| Gene expression |
PPARγ GATA3 FOXA1 UPK1A UPK2 KRT20 ESR2 |
PPARγ GATA3 FOXA1 UPK1A UPK2 KRT20 ESR2 |
PPARγ GATA3 FOXA1 UPK1A UPK2 KRT20 ESR2 |
Markers of smooth muscle, endothelium, fibroblasts, myofibroblasts |
KRT5 KRT6A KRT14 CD44 TGM1 DSC3 PI3 |
Synaptophysin CGA NSE/CD56 |
| Genomic alternation |
FGFR3 KDM6A CDKN2A |
ELF3 PPARγ |
PPARγ E2F3 SOX4 ERCC2 TP53 |
TP53 or RB1 |
TP53 and RB1 | |
| Infiltration | No | Stromal cells—fibroblasts, immune cells—B and T lymphocytes | No |
Stromal cells Immune—T- and B-cell |
Immune cells—Cytotoxic lymphocytes Natural killer cells |
No |
| Prognosis | the best | Poor | Intermediate | Intermediate | Poor | The poorest |