Table 3.

NMIBC subtypes and their molecular features. Most of Hurst´s subtypes of Ta tumors are classified as class I, T1E1 subtype cases are classified as class I, IIb or III

The Aarhus group classification	Class I	Class IIa	Class IIb	Class III
Gen e expression	Uroplakins	Uroplakins KRT20 KRT14	Uroplakins KRT20 KRT14	KRT5 KRT15 KRT14 CD44 GATA3
Regulon activity		FOXM1 ESR2 ERBB2 ERBB3	ESR1 FGFR1 RARB STAT3 PGR	AR GATA3
Molecular feature	Early stage, high expression of early cell cycle genes	High expression of late cell cycle genes	The highest immune infiltration of NMIBC	Dormant state of disease
Prognosis	Good	The poorest	Poor

Lund taxonomy applied to NMIBC	UroA	UroB	UroC	GU
Expression	Urothelial differentiation signature, FGFR3	KRT5 CDH3 MYC	MYCL MYCN	MYCL MYCN
Genomic alternation	FGFR3 KDM6A RAS TERT PIK3CA	RAS CDKN2A deletion Loss of TP53 TERT PIK3CA	TP53 TERT PIK3CA	RB1 TP53 Loss of TP53 Loss of RB1 E2F3 amplification TERT PIK3CA

T1E4 and part of T1E2 cases are classified as IIa. T1E3 cases are classified as class IIb