|
Drug
|
Purpose
|
Solid lipid
|
Liquid lipid
|
Surfactant
|
Formulation method
|
Outcome
|
Ref.
|
| Miltefosine |
Prolong drug release of anticancer drug |
Stearic acid |
Oleic acid |
Tween 80 |
Microemulsion technique |
In vitro and in vivo studies in tumor bearing mice show sustained drug release with increased blood circulation and reduction in clearance rate as well as increased hemolytic properties with respect to free drug in mouse. |
79
|
| Carvacrol |
Anti-leishmanial NLC for increasing systemic residence time with less toxicity |
Stearic acid |
Beeswax |
Poloxamer 188 |
Microemulsion technique |
In vitro results show initial burst release followed by sustained drug release unlike free drug which show quick release. In vivo results show increased half-life and low clearance of drug loaded in NLC with less cytotoxicity. |
80
|
| Doxorubicin |
Delivery of pH sensitive anticancer drug coupled with tocopherol succinate through amide and hydrazone conjugate |
Compritol |
Docosahexaenoic acid |
Tween 80 |
Emulsion ultrasonication technique |
pH sensitive hydrazone bond shows controlled release from NLC. In vivo studies show better pharmacokinetic profile and reduced tumor growth with decrease in drug induced toxicity in mice. |
84
|
| Resveratrol |
RBC membrane coated NLC containing rabies virus glycoprotein and triphenylphosphine cation molecule for antioxidant delivery to neuronal mitochondria for Alzheimer's disease |
Cetyl palmitate |
Oleic acid and cholesterol |
Tween 80 |
Modified emulsification ultrasonication method |
RBC encapsulation result in higher biocompatibility and sustained drug release. in vivo studies in mice shows dual modified NLC can cross BBB and deliver antioxidant to specifically to neuronal mitochondria. |
81
|
| Sesamol |
Delivery of antioxidant and neuroprotective agents to patients suffering from ischemic stroke |
Cetyl palmitate |
Oleic acid |
Polaxomer 188 and Tween 80 |
High pressure homogenization |
Sesamol loaded intravenous injection of NLC show reduced cytotoxicity, cellular damage and oxidative stress in rats, while free Sesamol failed. |
82
|
