Table 2.
Antimicrobial, hemolytic, and cytotoxic activities of peptoids
| # | MIC a) (µM) | HC10/HC50 b) (µM) | H max c) (100 µM) | Selectivity index d) | LC50 e) (µM) | ||
|---|---|---|---|---|---|---|---|
| E. coli ATCC25922 | S. aureus ATCC25923 | MRC‐5 | HaCaT | ||||
| 1 | 6.3 | 1.6 | 8.3/22.9 | 112.3 ± 0.7 | 1.3 | 8.1 | 7.3 |
| 10 | 3.1 | 1.6 | 6.6/17.0 | 108.1 ± 1.7 | 2.1 | ndf | ndf |
| 11 | 6.3 | 1.6 | 8.3/22.2 | 103.4 ± 3.2 | 1.3 | 6.9 | ndf |
| 14 | 3.1 | <0.8 | 23.6/43.4 | 90.0 ± 7.3 | 7.6 | 9.7 | ndf |
| 29 | 6.3 | 6.3 | >100/>100 | 9.8 ± 1.8 | >15.9 | 11.8 | 18.8 |
| 32 | 6.3 | 3.1 | 77.7/>100 | 15.9 ± 1.5 | 12.3 | 14.5 | 17.1 |
| 45 | >25 | 25 | >100/>100 | 4.5 ± 0.2 | ndf | ndf | ndf |
| Melittin | 12.5 | ≤ 1.6 | <3.1/4.0 | 105.7 ± 17.6 | <0.2 | ndf | ndf |
| Buforin‐II | 12.5 | 12.5 | ndf | ndf | ndf | ndf | ndf |
| Omiganan | 12.5 | 12.5 | >100/>100 | 0 | >8.0 | ndf | ndf |
| Pexiganan | 3.1 | ≤ 1.6 | >100/>100 | 8.2 ± 0.6 | >32.3 | ndf | ndf |
a)
These concentrations represent mean values of triplicates.
b)
HC10 and HC50 are the concentrations of compounds causing 10% and 50% hemolysis in rat erythrocytes, respectively. These concentrations represent mean values of triplicates.
c)
H max is the percentage (%) of hemolysis at the highest concentration tested (100 µM).
d)
The selectivity index was calculated by dividing HC10 by the MIC value against E. coli ATCC 25 922.
e)
LC50 is the concentration of the compounds resulting in 50% of the cells being killed.
f)
Not determined.