Table 3.
Antimicrobial activity of selected peptoids against pathogenic and MDR strains (MIC, µM)
| # | Pathogenic strains | MDR strains | ||||||
|---|---|---|---|---|---|---|---|---|
| E. faecium KCTC 13225 | E. faecalis KCTC 3511 | P. aeruginosa a KCTC 1637 | S. typhimurium SL 1344 | P. aeruginosa MDR‐198 | E. coli ESBL 63103 | K. pneumonia ESBL 61962 | S. aureus MRSA C623 | |
| 1 | <0.8 | 0.8 | 6.3 | 25 | 6.3‐12.5 | 3.1‐6.3 | 6.3‐12.5 | 1.6‐3.1 |
| 10 | 12.5 | 12.5 | nd b | 12.5 | nd b) | nd b) | nd b) | nd b) |
| 11 | <0.8 | <0.8 | 3.1 | 25 | 6.3–12.5 | 3.1–6.3 | 6.3–12.5 | 3.1–6.3 |
| 14 | <0.8 | 1.6 | nd b) | 12.5 | nd b) | nd b) | nd b) | nd b) |
| 29 | 1.6 | 3.1 | 3.1 | 6.3 | 6.3–12.5 | ≥25 | >25 | 3.1–6.3 |
| 32 | 3.1 | 6.3 | nd b) | 6.3 | 6.3–12.5 | 12.5–25 | 12.5–25 | 3.1–6.3 |
All concentrations represented mean values of triplicates. E. faecium, E. faecalis, and S. aureus are gram‐positive, P. aeruginosa, S. typhimurium, E. coli, and K. pneumonia are gram‐negative strains.
a)
P. aeruginosa was maintained in refined LB media.
b)
Not determined. MDR: multi‐drug resistant, ESBL: extended spectrum β‐lactamase, MRSA: methicillin‐resistant S. aureus.