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. 2023 Jun 21;10(24):2300881. doi: 10.1002/advs.202300881

Figure 4.

Figure 4

ANO1 contributes to an immune‐suppressive tumor microenvironment. A) ANO1 knockdown in MC38/CT26 cells. For CT26 CDX, changes of in vivo B) tumor growth, C) IHC‐staining of infiltrated CD8/granzyme B/PD‐L1, D) IHC‐based quantification of infiltrated CD8/granzyme B/PD‐L1, and E) ELISA‐based expression of IFN‐γ/TNF‐α/granzyme B/IL‐13/IL‐4 in xenograft tumors were measured after ANO1 knockdown. F) An overview for mIHC‐categorized density of five major immune cells in TIME of 70 GC patients. G) Representative images and statistics of each major immune cells in GC patient specimens, whose density were stratified by ANO1 positivity. *p < 0.05. ns, not significant. Error bars, mean ± SEM.