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. 2023 Jun 21;10(24):2300881. doi: 10.1002/advs.202300881

Figure 7.

Figure 7

ANO1 impairs ferroptosis through activating PI3K‐Akt signaling. A) RNA‐sequencing identified genes downregulated in HGC27 cell after ANO1 knockdown were proceeded for KEGG enrichment analysis. B) ANO1‐related enrichment of PI3K‐Akt signaling in TCGA/GSE62254 datasets. C) ANO1 knockdown in GC cells deactivated PI3K‐Akt signaling. PI3K‐Akt signaling inhibitor Dactolisib (Dacto) abrogated D) the NRF2/SLC7A11 upregulation, and rescued the E) lipid ROS/F) MDA inhibition. The color scale from blue to red reflected the p value from 1 to 0 (the smaller, the more significant). *p < 0.05. Error bars, mean ± SEM.