TABLE 2.
Comparison of cytokines concentration in the perfusate at the beginning (T0) and at the end (Tf) of ex-vivo lung perfusion with and without CytoSorb® in transplanted grafts.
| No-Cytosorb (n = 11) | Cytosorb (n = 16) | p-value | |
|---|---|---|---|
| IL-6 log10 T0 | 2.1 ± 1.7 | 3.5 ± 0.7 | 0.0577 |
| IL-6 log10 Tf | 4.8 ± 0.2* | 4.3 ± 0.4* | 0.0002 |
| IL-6 log10 delta | 2.8 ± 1.7 | 0.9 ± 0.7 | 0.0014 |
| IL-10 log10 T0 | 1.1 ± 0.5 | 1.1 ± 0.5 | 0.9172 |
| IL-10 log10 Tf | 2.7 ± 0.4* | 1.9 ± 0.3* | 0.0000 |
| IL-10 log10 delta | 1.6 ± 0.5 | 0.8 ± 0.6 | 0.0027 |
| MCP1 log10 T0 | 3.0 ± 0.5 | 2.6 ± 0.6 | 0.0709 |
| MCP1 log10 Tf | 3.8 ± 0.2* | 3.0 ± 0.4** | 0.0000 |
| MCP1 log10 delta | 0.8 ± 0.4 | 0.4 ± 0.6 | 0.0229 |
| GCSF log10 T0 | 0.7 ± 1.1 | 1.7 ± 0.9 | 0.0242 |
| GCSF log10 Tf | 3.8 ± 0.6* | 3.3 ± 0.6* | 0.0457 |
| GCSF log10 delta | 3.1 ± 0.8 | 1.4 ± 1.0 | 0.0002 |
List of abbreviations: IL-6, interleukin 6; IL-10, interleukin 10; MCP1, monocyte chemotactic protein 1; GCSF, granulocyte colony-stimulating factor; log10, natural logarithm; *p < 0.01 vs. T0; **p < 0.05 vs. T0.