TABLE 3.
Comparison of recipient and donor characteristics in transplanted grafts after ex-vivo lung perfusion with and without CytoSorb®.
| Cytosorb (n = 16) | no-Cytosorb (n = 22) | p-value | |
|---|---|---|---|
| Baseline LTx recipient characteristics | |||
| LAS score | 31.2 [30.8–31.3] | 31.4 [30.7–31.6] | 0.28 |
| Age at transplant (years) | 60 [54–63] | 49 [35–57] | 0.02 |
| Male sex (n, %) | 10 (63) | 13 (59) | 0.80 |
| ECMO at LTx (n, %) | 0 (0) | 2 (9) | 0.49 |
| Bilateral lung transplantation (n, %) | 10 (63) | 21 (95) | 0.01 |
| CPB during LTx (n, %) | 5 (31) | 16 (73) | 0.01 |
| Ischemia time (min) | 784 ± 96 | 781 ± 33 | 0.9 |
| Lung disease | |||
| Idiopatic fibrosis | 8 | 7 | |
| Cystic fibrosis | 2 | 5 | 0.9 |
| COPD | 4 | 6 | |
| Vascular disease | 1 | 3 | |
| Other | 1 | 1 | |
| Baseline donor characteristics | |||
| Age (years) | 50 [38–53] | 48 [38–53] | 0.9 |
| Smoker (n, %) | 9 (41%) | 7 (44%) | 0.2 |
| Time on mechanical ventilation (days) | 3 ± 2 | 4 ± 2 | 0.02 |
| P/F (mmHg) | 311 ± 157 | 337 ± 107 | 0.5 |
| PaO2 with FiO2 0,4 (mmHg) | 125 ± 52 | 125 ± 29 | 0.9 |
| P/F > 350 | 6 (38%) | 11 (50%) | 0.5 |
| Cause of death | |||
| Cerebral hemorrhage | 6 | 16 | |
| Anoxic brain injury | 3 | 3 | 0.7 |
| Trauma | 4 | 1 | |
| Other | 3 | 2 | |
List of abbreviations: EVLP, ex vivo lung perfusion; ECMO, extracorporeal membrane oxygenation; LTx, lung transplantation; CPB, cardiopulmonary bypass; COPD, chronic obstructive pulmonary disease; P/F PaO2/FiO2 ratio; PF/100.