Pedigree of families F2, F3, and F5
Probands are highlighted by arrow. Black symbols indicate family members with history of cancer. Square symbols indicate males, circles females, and diamonds sex unspecified. A number within a square/circle/diamond refers to number of individuals represented by the symbol if more than one individual. A line through a symbol indicates that the individual is deceased. +, TINF2 p.(Arg265Ter) variant carriers. ?, not tested for TINF2 p.(Arg265Ter) variant. A Family F2. B Family F3. C Family F5.