Figure 2.

Telomere length results of three TINF2 p.(Arg265Ter) variant carriers

Analysis performed by flow-FISH (with permission from RepeatDx Europe). Results show median telomere length percentiles in lymphocytes compared to age-matched controls, shown in graphical form (A) and as a table (B). Square: proband from family 1. Triangle: proband from family 2. Circle: proband from family 3. Abbreviations are as follows: MTL, patient medial telomere length. MTLN, normal MTL at age (50^th percentile). INT, telomere length interpretation. VH, very high (≥99^th percentile). H, high (≥90^th and <99^th percentile). N, normal (≥10^th percentile and <90^th percentile). L, low = (≥1^st percentile and <10^th percentile). VL, very low (<1^st percentile). As presented, family one and two had a median telomere length of lymphocytes overall above the 99^th percentile, whereas family three had between the 90^th and 99^th percentile.