Table 1.
The regulation of lactylation in cancer cells.
| Cancers | Lactylated protein(s)/site(s) | Function | References |
|---|---|---|---|
| Prostate cancer | HIF-1α | Promote angiogenesis | (66) |
| H3K18 | Neuroendocrine differentiation | (90) | |
| T-cell acute lymphoblastic leukemia |
ALDOA | Metabolic Reprogramming | (47) |
| Colorectal cancer | ALDOA | Metabolic Reprogramming | (47) |
| Liver cancer | AK2 | Regulate p53 pathway and lead to poor prognosis | (48) |
| CCNE2 | Promote tumor proliferation | (91) | |
| H3K9la, H3K56la | Promote tumorigenesis | (92) | |
| Non-small cell lung cancer | H3 | Inhibit glycolysis | (11) |
| H3K18 | Neuroendocrine differentiation | (90) | |
| Ocular melanoma | H3K18 | Upregulate the oncogene YTHDF2 and promote tumorigenesis |
(12) |
| Anaplastic thyroid cancer | H4K12 | Cause cell cycle dysregulation and promote tumor proliferation |
(93) |
| Clear Cell Renal Cell Carcinoma |
H3K18 | Activate the transcription of PDGFRβ and promote tumor proliferation |
(94) |
| Breast cancer | H3K9,18,23,27,56,122 H4K5,8,12,31,77,91 |
N/A | (9) |
| Cervical cancer | H3K9,18,23,27,56,122 H4K5,8,12,31,77,91 H2AK11,13,115 H2BK5,11,15,16,20,23,43,85, 108,116,120 |
N/A | (9) |
HIF-1α, Hypoxia-inducible factor-1alpha; ALDOA, aldolase A; AK2, adenylate kinase 2; CCNE2, cyclin E2; YTHDF2, Human YTH domain family 2; PDGFRβ, platelet-derived growth factor receptor β.
N/A means "not applicable". It means that the function of these Kla sites has not been reported.